Every day over 22,000 people around the world die due to neoplastic diseases. In Europe in 2012, over 400 K of new cases of prostate cancer were diagnosed with over 92 K deaths. Globally almost 110 K new patients were diagnosed in 2012 and almost 31 K died because of it.
Current therapeutic methods are mainly invasive and can permanently damage the prostate’s functionalities. Lower risks and more directed doses of radiation help to lower progress of disease and reach even metastatic areas.
The aim of the company is to create products capable of higher precision and less side effects in cancer imaging and radiotherapy. NanoThea is able to achieve this by closing well known radioisotopes in our polysaccharide nanoparticles and targeting system. The unique features of our product are:
– the nanoparticles’ structure allows high tumor/blood ratio, increasing safety of the radiotherapy
– appropriate engineered linker for targeting molecule
– radiochemical stability
– lack of toxicity of the carrier – materials approved by FDA for safety (dextran)
– radiolabeling in situ in the hospital, before administration
As Henry Ford once wished to
build a car for everybody
our mission is to give every patient
chance for a reliable and precise diagnostics and early cancer detection.
To create nanoparticle that reaches even first few tumor cells
and join forces to accelerate it to every hospital.
NanoThea is developing an innovative radiopharmaceutical for PET diagnosis and treatment of patients with metastatic tumors that are resistant to current used therapies. Our main goal is to create a precise tool for prostate cancer PET diagnostics and focal brachytherapy.
The innovative approach to the radioisotope carrier focuses on maximizing availability of nanoparticles for cancer cells spread within the organism. To maximize the efficiency our products are characterized with higher tumor/blood ratio when compared to current solutions which increases safety and efficacy of solution.
In the future, the company wants to combine diagnostic methods – using PET/MR with treatment. NanoThea will use a molecule that can bind with various types of radioisotopes/elements using our nanoparticle for different diagnostic methods: e.g. using radioactive Ga or Cu for PET diagnostics and Gd for MRI and Lu or Y for treatment. The next and final step is surface modification, not only for adjustment of zeta potential but also for precise targeting with oligopeptides or antimetabolites.
Due to very invasive methods of treatment nowadays – there is a possibility of adaptive shortcuts for clinical pathway. We intend to combine the procedure for both applications, thus minimizing time and costs dedicated for the trials.
Since 2012 we started to work on nanotechnology for cancer treatment and diagnosis.
In BioMedical Engineering Laboratory, established by prof. Tomasz Ciach at Warsaw University of Technology, we developed novel nanoparticles for cancer treatment using chemotherapeutics.
As a step forward after our first adventure with encapsulating drugs inside nanoparticles we decided to create nanoparticles for cancer diagnostics. We focused our research on two methods: fluorescence and radioisotopes. With combining these two methods we are able to track on-line the fate of nanoparticle in the organism. Thanks to radioisotopes even small signal from few cancer cells is visible on the PET scan. Our ideas and attitude attracted attention of two VC companies. In September 2015, together with Giza Polish Ventures and StartVenture@Poland we founded NanoThea to commercialize the innovative tool for cancer diagnostics. Now we are working to go global with our idea.
PhD hab., Associated Professor
at Warsaw University of
Technology, specialist in the field
of Biomedical Engineering,
inventor of three products
introduced to the market,
author of more than 20 patents
and patent applications.
Biotechnologist, PhDc on Warsaw
University of Technology, specialist
in nano-solutions for cancer treatment.
Gathered her experience on
and in NanoVelos Start-up research team.
Chemist, graduated from
Chemical Department of Warsaw
University of Technology.
Member of BioMedical
at the Faculty of Chemical
and Process Engineering WUT.
Biotechnologist, PhDc at Warsaw
University of Technology, member
of BioMedical Engineering
Laboratory at the Faculty of
Chemical and Process
PhD at Institute of Organic Chemistry, Polish Academy of Sciences (IChO, PAS); M.Sc. at Chemical Department of Warsaw University of Technology (WUT). Organic Chemist experienced in organic synthesis, supramolecular chemistry and interested in bioconjugation, biopolymer chemistry.
Surgeon, specialized in both colorectal and bariatric surgery as well as phlebology. Worked as medical advisor in PFIZER Inc., CEO in BIOIVEST 2005 SA, a small pharmaceutical company for humans and productive animals and Vice-President for R&D in BIOLEK Ltd (BIOTON SA GROUP). Co-inventor of patent and co-author of the marketed success of the product widely used in gastroenterology.
PhD in Biochemistry. Gained his scientific experience at Warsaw University of Life Sciences, University of Potsdam and Nencki Institute of Experimental Biology PAS.
Chemist, graduated from Chemical Department of Warsaw University of Technology and Chemical Metrology of Warsaw University. Specializes in quality control, validation, quality system in laboratory and chemical analytics.
Biotechnology Engineer, graduated from Faculty of Chemistry of Warsaw University of Technology. Participant of Master Studies at WUT on a speciality of Bioengineering.
graduated from Mechatronic Department of Warsaw
University of Technology, Mechanical Department
of Lublin University of Technology and
Medical Department of Medical University of Lublin,
An entrepreneur, founder
of Internet businesses.
Experienced in setting up
new life science businesses.
Partner at Polish-Israeli
VC – Giza Polish Ventures.
Diplomat, a specialist in the field
of Marketing, Media Relations,
Strategic Communications and
He served as President of the
Foundation for the Disabled
and worked as Advertising
Director of Data
and TV Center.
Management board member
with experience in VC, PE
and M&A. Executive officer
at seed capital funds, investing
in Polish and international
Start-Ups. Warsaw School
of Economics graduate (MSc)
and Universiteit van Tilburg.
We present improved tumor targeting delivery system, carrying diagnostic radioisotope for PET or SPECT detectors.
Our technology key features:
- Based on safe polymer nanocarrier
- Nanoparticles accumulate inside tumor tissue due to enhanced permeation and retention through the leaky blood vessels
- Confirmed non-toxicity and biocompatibility
- Universal – for various cancer cell types
- Theranostic approach – nanoparticles for diagnostics, also with potential therapeutic use
- Precise diagnostics exploiting radioisotopes
More details about Technology will be available immediately after patent submission.
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GRANTS FOR INNOVATION
Project co-financed by the European Regional Development Fund under the Operational Programme Innovative Economy.
SMART GROWTH OPERATIONAL PROGRAMME 2014-2020
Project co-financed by the National Centre for Research and Development under the Smart Growth Operational Programme 2014-2020.
MAZOVIAN REGIONAL OPERATIONAL PROGRAM FOR THE YEARS 2014-2020
Project co-financed by the the European Regional Development Fund under the Mazovian Regional Operational Program for the years 2014-2020.